Dr Noble is a Consultant Clinical Oncologist at the Edinburgh Cancer Centre (ECC), Honorary Senior lecturer with Edinburgh University, NHS Scotland NRS Research Fellow, and Assistant Editor for Cinical Oncology. He completed undergraduate medical studies at the University of Cambridge, and trained as a Clinical Oncologist in the East of England, based at the Cambridge Cancer Centre. During training, Dr Noble won a 3-year Cancer Research UK Clinical Research Fellowship and completed a PhD investigating technical aspects of Adaptive Radiotherapy for Head & Neck Cancer, and moved to Edinburgh to take up a Consultant post in August 2020.
Dr Noble specialises in treating Head & Neck Cancer, and has an academic interest in advanced imaging, image analysis, and radiotherapy treatment techniques, biomarkers of disease and normal tissue response to radiation, and data science across all tumour types. He has an active portfolio of basic and translational research projects, works closely within the Edinburgh Radiotherapy Research Group led by Professors Duncan McLaren and Bill Nailon, with ENT colleagues from the ECC Head & Neck Unit including Mr Iain Nixon, and with Radiologist Dr Rishi Ramaesh. Projects funded by the Scottish Chief Scientists Office (CSO) include IMAGINE (grant no: TCS/17/26) – in which advanced radiomics and machine learning techniques are applied to on-treatment image guidance (IG) scans to look for predictors of more severe toxicity, PRISTINE (grant no: TCS/21/39), in which Scotlands only PET-MRI machine will be used to improve staging and treatment personalisation for men with high-risk early prostate cancer, and SR-1171 in which circulating tumour DNA is used to assess and monitor treatment response in patients who have undergone curative treatment for HPV-driven Head & Neck Cancer. In the PROSECCA project, funded by Prostate Cancer UK (grant no: MA-CT20-010), the research team aim to collate longitudinal health records, disease data, and radiotherapy planning and imaging data for all Scottish men who have been treated with IMRT to improve our ability to predict treatment response and side effects.
Dr Noble has a number of external collaborators including Dr. Claire Patterson and Professor Gareth Inman from the Beatson Cancer Centre in Glasgow - looking at using a combination of MRI imaging features, and genomic analysis to improve our ability to predict poor treatment response in high-risk oropharyngeal cancer, and with Dr Raj Jena from the Cambridge Cancer Centre in the CRUK-funded HAMLET study – the first propsective analysis of machine learning predictive models in radiation therapy. In addition, he works closely within the ECC Head & Neck trials team, led by Dr Devraj Srinivasan, which recruits extensively to national and international trials including COMPARE, PATHOS, POPPY, BURAN, and VERSATILE. Dr Noble would be please to discuss proposals for projects, trials, supervision, and further collaboration.
